Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival
نویسندگان
چکیده
منابع مشابه
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival
Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence ...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2015
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2015.130